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“It is simply no longer possible to believe much of the clinical research that is published, or to rely on the judgment of trusted physicians or authoritative medical guidelines. I take no pleasure in this conclusion, which I reached slowly and reluctantly over my two decades as an editor of The New England Journal of Medicine.”

~Marcia Angell MD, a well-known, respected physician, long-time editor of NEJM.
http://e-patients.net/archives/2009/10/a-quote-i-wont-soon-forget.html